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The mechanism and underlying cause of alopecia areta remains unknown, but we do know that it is caused when white blood cells begin to attack the hair follicles in the scalp and/or other parts of the body where there is hair, including the nostrils, eyelids and underarms. Hair follicles under attack shrink in size, causing them to decrease or cease hair production [propecia online]. For some people, hair loss is confined to the scalp, and is characterized by quarter-sized patches of loss. Other people suffer from complete hair loss on the head, or total hair loss on the entire body. Fortunately for the 4 million Americans who suffer from alopecia areta, the hair follicle is not permanently damaged, and always retains the potential to regrow hair. Several alopecia treatment options are available to stimulate the follicles.Male pattern hair loss or androgenetic alopecia is a common but poorly understood disorder. The influence of androgens and the type 2 5[alpha]-reductase enzyme in the pathogenesis of this condition are now well established. (1) 5[alpha]-reductase converts testosterone to the more active DHT, and the type 2 isoform is expressed in androgen-responsive tissues such as the hair follicle. The type 1 isoform of 5[alpha]-reductase is widely expressed in many tissues.Propecia Online (Merck & Co., Inc., Whitehouse Station, NJ) is an inhibitor of type 2 5[alpha]-reductase and is approved as Propecia (1 mg) for the treatment of male pattern hair loss. It is also approved as Proscar (5mg) for benign prostatic hyperplasia. Dutasteride is a potent inhibitor of both isoforms of 5[alpha]-reductase. (2) Avodart (dutasteride 0.5 mg, GlaxoSmithKline, Brentford, Middlesex, UK) is approved for the treatment of benign prostatic hyperplasia. In this phase II trial, the authors investigate the efficacy and safety of dutasteride at different doses in the treatment of androgenetic alopecia. They find that dutasteride suppresses DHT and improves clinical hair loss in a dose-dependent fashion. In men 21 to 45 years old over a 24-week period, dutasteride 0.1 or 0.5 mg daily is comparable to finasteride 5 mg daily, and dutasteride 2.5 mg is superior to finasteride. It is unclear if the increased efficacy of dutasteride is a function of more potent type 2 5[alpha]-reductase inhibition or its additional function as an inhibitor of type 1 5[alpha]-reductase [buy propecia online]. It is also unclear how the 2 drugs will compare with long-term use, as the maximal effects of finasteride on hair loss take place after 24 weeks of treatment. Neither drug is capable of completely reversing hair loss.

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Finasteride (fin-AS-tur-ide) belongs to the group of medicines called enzyme inhibitors. It is used to treat urinary problems caused by enlargement of the prostate (benign prostatic hyperplasia or BPH). In men with very enlarged prostates and mild to moderate symptoms (difficulty urinating, decreased flow of urination, hesitation at the beginning of urination, getting up at night to urinate), Propecia may decrease the severity of symptoms. Finasteride may also reduce the chance that surgery on the prostate will be needed.Propecia [online] blocks an enzyme called 5-alpha-reductase, which is necessary to change testosterone to another hormone that causes the prostate to grow. As a result, the size of the prostate is decreased. The effect of finasteride on the prostate lasts only as long as the medicine is taken. If it is stopped, the prostate begins to grow again.
Finasteride also is used by some balding men to stimulate hair growth. If hair growth is going to occur with the use of finasteride, it usually occurs after the medicine has been used for about 3 months and lasts only as long as the medicine continues to be used. The new hair will be lost within 1 year after propecia treatment is stopped.
Hair loss in men or women can contribute to the appearance of looking older than chronologic age. One of the hair restoration procedures may be used alone, or in combination with a procedure for facial skin rejuvenation to take years off of a patient’s apparent age.

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Any person who feels that hair loss is a problem should consult a dermatologist. The first step in treating hair loss is diagnosing its cause. Causes can include heredity, various acute and chronic diseases, nutritional deficiency, medications, radiation, and improper hair treatments.The most common cause of hair loss in men is male pattern baldness, a condition with a hereditary basis. In women the most common conditions are androgenetic alopecia baldness, and telogen effluvium which causes thinning of scalp hair but not bald patches. A condition of unknown cause called alopecia areata occurs in both men and women, causing hair loss in small circular patches [propecia online].Based on medical evaluation, a dermatologist will recommend the procedure that is right for the individual patient. Treatment options include:
-Male pattern baldness may be medically treated with topical minoxidil or oral finasteride, drugs that can restart hair growth in some patients.
-Hair restoration surgical procedures include hair transplant, scalp reduction, scalp extenders, and scalp lifts.

Five-year Propecia efficacy results

The studies assessed the efficacy of Propecia [online] by four separate endpoints: hair counts in a one-inch diameter circle of the scalp; assessments of “before” and “after” photographs by a panel of dermatologists; patient questionnaires and investigator assessments of changes in scalp hair growth. The effectiveness of Propecia vs. placebo was demonstrated as follows:
– Hair count: At the start of the studies, baseline hair counts averaged 876 hairs in a one-inch diameter area of scalp. By the end of the first year, men taking Propecia had an average of 126 more hairs than men taking placebo. This difference continued to grow, and, by the end of the fifth year, the net difference between the groups increased to 277 hairs in favor of the men taking [buy] Propecia. At the end of the fifth year, 65 percent of men taking Propecia (n=219) maintained or improved their hair count compared to their hair count at the start of the studies, while all of the men on placebo (n=15) lost hair count.
– Before and after photos: The panel of dermatologists who reviewed standardized clinical photographs of men treated with Propecia Physicians at the end of the five-year study rated 90 percent of men treated with Propecia as having had no further visible hair loss.

Men treated with Propecia were more likely to say that: their bald spot was getting smaller the appearance of their hair had improved; they had experienced increased hair growth.Men with androgenetic alopecia, treatment with finasteride 1 mg/d for five years leads to a marked and sustained reduction in the risk of developing further visible hair loss.The findings were reported here at the 20 th World Congress of Dermatology (WCD).
In two replicate, double-blind studies, men aged 18 to 41 years with androgenetic alopecia (AGA) received finasteride 1 mg or placebo for up to five years. Global photographic assessment of scalp hair growth by an expert panel showed the superiority of finasteride over placebo.In a post-hoc analysis, Dr. Keith Kaufman, of Merck Research Laboratories in Rahway, New Jersey, United States, and colleagues examined the effect of finasteride on the five-year risk of developing further hair loss based on these GPA data.
The analysis included 713 patients who received finasteride 1 mg/day (645 patients) or placebo (68 patients) continuously from randomisation to study completion or discontinuation. All patients underwent global photographic assessments during the five-year study period.Propecia treatment led to a 93 percent reduction in the risk of developing further visible hair loss from baseline to end point, relative to placebo. Development of further visible hair loss was observed in the majority of placebo-treated patients by year 3 [buy propecia online].The highest rates of further visible hair loss for placebo patients occurred in men of younger age, earlier onset of hair loss, longer duration of hair loss, more severe hair loss pattern, and/or parental history of hair loss.